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Embryology: Meiosis

Interphase.

Meiosis I.

  • Generates the most diversity.
  • Starts diploid.
  • Prophase 1. DNA has already been replicated prior to Meiosis I. Homologous chromosomes pair (bivalents) to form synapses. Chromosomes condense.
  • Bivalent. Has 2 chromosomes and 4 chromatids. A pair of homologous chromosomes.
  • Homologous chromosomes. One maternal chromosome and one paternal chromosome.
  • Synapses. Crossover “mutations” can occur when homologous chromosomes pair up.
  • Synaptonemal complex. Protein that holds homologuess together.
  • Prometaphase 1. Nuclear membrane disappears. One kinetochore per one chromosome (instead of per chromatid). Chromosomes attach to spindle fibers.
  • Metaphase 1. Bivalents (2 chromosomes, 4 chromatids) align at metaphasic plate.
  • Anaphase 1. Chiasmata separate. Chromosomes (each with 2 chromatids) move to opposite poles. Each daughter is now haploid (n).
  • Telephase 1. Nuclear envelope may reform or it may just go into Meiosis 2.
  • Chiasmata. The point where paired chromosomes remain in contact together during meiosis 1. X-shape area. Help keep homologues together after synaptonemal complex breaks down.
  • Ends haploid.

Meiosis 2.

  • There is no copying of DNA when going from Meiosis I to Meiosis II.
  • “Meiosis for haploid cells”.
  • Starts haploid.
  • Meiosis 2 is shorter and simpler.
  • Cells entering are haploid. They have one chromosome from each homologous pair. Each chromosome still has 2 sister chromatids.
  • Prophase 2. Nuclear envelope (if it had reformed prior) breaks. Chromosome condense.
  • Prometaphase 2. Spindle is fully formed. Each sister chromatid forms an individual kinetochore that attaches to spindle.
  • Metaphase 2. Sister chromatids line up at metaphasic plate.
  • Anaphase 2. Sister chromatids split up and move to opposite poles. Pulled apart by kinetochore microtubules.
  • Telophase 2. Chromosomes decondense. Nuclear envelope reforms. Cytokinesis. Results with 4 haploid cells.
  • Ends haploid.

Resources.